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KMID : 0361020210640110800
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Korean Journal of Otolaryngology - Head and Neck Surgery
2021 Volume.64 No. 11 p.800 ~ p.805
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Role of the TAS2R38 Bitter Taste Receptor Gene Single Nucleotide Polymorphism in Patients With Taste Disorders
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Kang Byung-Jun
Park Jin-Woo
Geum Sang-Yen
Kim Un-Kyung
Shin Seung-Heon
Ye Mi-Kyung
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Abstract
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Background and Objectives Several studies have shown that three single nucleotide polymorphisms(SNPs) in the TAS2R38 gene demonstrate a strong association with the ability tosense the bitter taste of phenylthiocarbamide (PTC) in. We have previously reported aboutTAS2R38 genotypes in normal volunteers. The aim of this study was to investigate the roleTAS2R38 gene plays in taste disorder by examining SNPs in the TAS2R38 gene in taste disorderpatients.
Subjects and Method Ninety-four patients with taste dysfunction from multiple etiologieswere enrolled. The genotypes were defined by identifying SNPs on the TAS2R38 gene. Theproportion of different TAS2R38 genotypes in the group was compared with that in the normalvolunteers of our previous study. The whole mouth taste threshold tests were performedand the thresholds were compared among the three different genotypic groups.
Results The proportion of each diplotype in taste disorder patients were as follows: PAV/PAV 36.2% (34/94), PAV/AVI 34.0% (32/94), and AVI/AVI 29.8% (28/94). The proportion ofAVI/AVI type was higher in the group than in the normal volunteers (p=0.031). The detectionand recognition thresholds of all four basic tastes were increased in the order of PAV/PAV,PAV/AVI, and AVI/AVI genotypes.
Conclusion The proportion of AVI/AVI homozygous was significantly higher in taste disorderpatients than in the normal volunteers. Our findings suggest that the genotypes of TAS2R38may represent one of the risk factors responsible for the development of taste disorders.
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KEYWORD
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Genetics, Phenylthiocarbamide, Polymorphism, Single nucleotide, Taste disorders, Taste receptors, type2
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